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鍙︿竴鏂归潰锛屽績鐞嗗眰闈㈠彈鍒扮殑褰卞搷鏄渶鐩存帴鐨勶紝涓嶄粎璁╁勾杞荤鐮斾汉鍛樺涓汉瀛︽湳鍚嶅0鍜岃亴涓氬墠閫旂劍铏戯紝鏇村鏄撳瀛︽湳鍚堜綔鐢氳嚦鏁翠釜绉戝鐣屼骇鐢熶俊浠诲嵄鏈猴紝杩欑宸ㄥぇ鐨勫績鐞嗗垱浼ゅ彲鑳藉洜姝よ浠栦滑褰诲簳鏀惧純瀛︽湳浜嬩笟銆傚綋鐒讹紝涔熸湁涓€浜涘唴蹇冨己澶х殑瀛﹁€咃紝浠栦滑浼氬洜涓鸿繖娈电粡鍘嗛噸鏂板瑙嗙瀛︾爺绌讹紝浠ユ洿涓ヨ皑鐨勬€佸害杩涜宸ヤ綔锛岃繖鏄汉浠笇鏈涜鍒扮殑缁撴灉銆?/p>

鎬昏€岃█涔嬶紝绉戝姹傜湡姹傚疄锛屽寘鎷浘鐗囬€犲亣鍦ㄥ唴鐨勪笉绔涓鸿缁濆鎶靛埗銆備笉瀹岀編鐨勫浘鐗囧苟涓嶅彲鎬曪紝鍙€曠殑鏄笉鍔犵害鏉熺殑閫犲亣琛屼负锛岀粰绉戠爺浜哄憳鍒蜂笂闅句互娲楀幓鐨勬薄鐐癸紝璁╃瀛︿抚澶辩湡瀹炪€佽瘹淇★紝璐诲鏃犵┓銆?/p>

鍙傝€冭祫鏂?/strong>

https://www.pnas.org/doi/full/10.1073/pnas.2213288119

https://www.pnas.org/doi/full/10.1073/pnas.2213287119

https://www.pnas.org/doi/full/10.1073/pnas.2213285119

https://www.pnas.org/doi/full/10.1073/pnas.2213289119

https://www.biorxiv.org/content/10.1101/2022.07.11.499380v1

https://www.biorxiv.org/content/10.1101/2022.06.15.492526v1

https://www.biorxiv.org/content/10.1101/2022.06.27.497729v1

https://www.nature.com/articles/d41586-021-02610-7

https://osf.io/kgyc6

https://portlandpress.com/biochemj/article/434/3/571/80024/Activation-of-hypoxia-inducible-factor-1-in-human

https://www.pubpeer.com/search?q=gregg+semenza

https://www.nature.com/articles/d41586-022-03032-9

鍑哄搧锛氱鏅腑鍥?/p>

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