澶╃敓鏃犵棝銆侀浂鐒﹁檻锛屾嫢鏈夎繖浜涜秴鑳藉姏浣犲氨鑳界湡鐨勫揩涔愪
更新时间:2022-11-29
|
锛堝浘鐗囨潵婧愶細pxhere锛?/p> 鎾版枃 | 闃垮ù 瀹℃牎 | Skin 褰撲綘鍥犱负鎵嬫寚鍒掍机銆佽蛋璺憯鍊掋€佽浆韬挒鍒伴棬妗嗚€岀棝寰楀樁鍝堝樁鍝堢洿鍚稿喎姘旀椂锛屼綘鏄惁涓嶆涓€娆″湴骞绘兂杩囷細瑕佹槸鑷繁鎷ユ湁鎰熷彈涓嶅埌鐥涜鐨勮秴鑳藉姏灏卞ソ浜嗭紒 鐢熸椿鍦ㄨ嫃鏍煎叞鐨勪箶路鍗℃闅嗭紙Jo Cameron锛夊氨鎷ユ湁杩欐牱鐨勮秴鑳藉姏銆傚叓宀佺殑濂规憯鏂簡鑳宠唺锛屼絾娌℃湁浠讳綍搴旀湁鐨勭棝瑙夛紝鐩村埌鍑犲ぉ鍚庡ス鍙戠幇鑳宠唺鐨勮搴﹀緢涓嶅鍔叉椂锛屾墠灏嗚繖浠朵簨鎯呭憡璇夊ぇ浜恒€?/p>
鈥滆秴浜衡€濆ザ濂垛€斺€斾箶路鍗℃闅嗭綔The Guardian 鍏崄澶氬勾鏉ワ紝濂圭粡鍘嗕簡鏃犳暟娆″彈浼わ紝鍗存劅瑙変笉鍒颁换浣曠柤鐥涖€?/strong>鍗℃闅嗗苟娌℃湁鎰忚瘑鍒拌嚜宸辩殑涓庝紬涓嶅悓锛屾棩甯哥敓娲讳腑鍙戠敓鐨勪篃涓嶈繃鏄細鐩村埌闂诲埌鐑х劍鑲夊懗鏃舵墠娉ㄦ剰鍒拌嚜宸变笉灏忓績闈犲湪浜嗘粴鐑殑鐐夊瓙涓婏紝浠ュ強璁╀紬澶氬コ鎬х棝鐨勬挄蹇冭鑲虹殑鍒嗗ī鍦ㄥス鐪嬫潵涔熷彧鏄鈥滃挴鍚扁€濅簡涓€涓嬶紝杩欐牱鐨勮澶氣€滀笉鐥涗笉鐥掔殑灏忎簨鈥?/strong>銆傜洿鍒板崱姊呴殕66宀佺殑涓€鍦烘墜鏈紝鎵嶈濂瑰交搴曡璇嗗埌鑷繁鏄涔堢嫭鐗广€?/p> 鍗℃闅嗘棩甯歌蛋璺椂鎬绘槸涓€鐦镐竴鎷愶紝鐢变簬娌℃湁鐤肩棝鎰燂紝澶氬勾鏉ュス涔熸病鏈夊お杩囬噸瑙嗚繖涓簨鎯呫€傚湪涓€娆″鑷€閮ㄧ殑X鍏夋鏌ヤ腑锛屽尰鐢熷彂鐜板ス鐨勯珛鍏宠妭宸茬粡涓ラ噸閫€鍖栵紝蹇呴』瑕佹帴鍙楅珛鍏宠妭缃崲鎵嬫湳锛岃€屽湪鏈悗鐨勪綇闄㈡湡闂达紝鍖荤敓鍙堟敞鎰忓埌浜嗗ス鐨勬媷鎸囧彈鍒板叧鑺傜値鐨勪弗閲嶅奖鍝嶈€屽彉褰紝浜庢槸鍙堝畨鎺掍簡绗簩娆℃墜鏈€?/p> 鍦ㄨ繖涓ゆ鎵嬫湳鏈熼棿锛屽崱姊呴殕浠庢湭鍚戝尰鐢熺储瑕佽繃鏈悗姝㈢棝鑽?/strong>锛岃繖浠ょ洃鎶ゅス鐨勫尰鐢烡evjit Srivastava闈炲父闇囨儕锛屼簬鏄皢濂逛粙缁嶇粰浜嗕机鏁﹀ぇ瀛︾殑鐤肩棝涓撳銆?/p> 涔斅峰崱姊呴殕鍜屽ス鐨勭埗姣嶏綔UCL瀹樼綉 鍦?019骞?鏈堝彂琛ㄥ湪British Journal of Anaesthesia鏈熷垔涓婄殑涓€浠界爺绌舵姤鍛婁腑锛屼机鏁﹀ぇ瀛﹀拰鐗涙触澶у鍒嗗瓙鐥涜鐮旂┒鍥㈤槦浠嬬粛浜嗕粬浠槸濡備綍鐮旂┒鍗℃闅嗙殑DNA锛屼互浜嗚В鏄粈涔堣濂规棤娉曞儚甯镐汉涓€鏍蜂骇鐢熺棝瑙夈€?/p> 鐮旂┒鍙戠幇锛?strong>鍗℃闅嗗熀鍥犱笂瀛樺湪涓や釜闈炲父鏄捐憲鐨勭獊鍙橈紝鏃㈠彲浠ユ姂鍒剁柤鐥涘拰鐒﹁檻锛岃繕鑳藉鍔犲垢绂忔劅锛屼績杩涗机鍙ｆ剤鍚?/strong>銆?/p> FAAH鐨勮瘉浠剁収锝淲ikipedia 绗竴涓獊鍙樺湪鏅€氫汉缇や腑闈炲父甯歌锛屽畠鎶戝埗浜嗚剛鑲吀閰拌兒姘磋В閰讹紙FAAH锛夌殑娲绘€?/strong>銆侳AAH鍦ㄨ剳涓垎甯冨箍娉涳紝鍏锋湁鍒嗚В涓€绯诲垪鍏锋湁涓嶅悓鐢熺悊浣滅敤鐨勭敓鐗╂椿鎬ц剛璐紙鍖呮嫭鍐呮簮鎬уぇ楹绘瘨绱燗EA锛夌殑閲嶈鍔熻兘銆?/p> 鐮旂┒鍛樺湪灏忛紶涓?strong>鏁查櫎璇ュ熀鍥犲悗锛屽彂鐜板皬榧犱綋鍐呯殑鍐呮簮鎬уぇ楹荤礌鐨勬按骞虫彁楂樹簡
浜虹被1鍙锋煋鑹蹭綋鏄剧ずFAAH鍜孎AAH-OUT寰己澶辩殑鍩哄洜缁勫浘銆傦綔鍙傝€冭祫鏂橻1] 绗簩涓獊鍙樻槸涓€涓柊鍙戠幇鐨勫亣鍩哄洜锛岀爺绌朵汉鍛樺皢鍏跺懡鍚嶄负鈥淔AAH-OUT鈥濄€傚亣鍩哄洜鏄湁缂洪櫡鐨勫姛鑳藉熀鍥犵殑澶嶅埗浣擄紝铏界劧鍦ㄥ簭鍒楃粨鏋勪笂涓庡姛鑳藉熀鍥犵浉浼硷紝浣嗗嵈涓уけ浜嗘甯哥殑铔嬬櫧璐ㄧ紪鐮佸姛鑳?/strong>銆傜爺绌朵汉鍛樿涓猴紝杩欎釜鍋囧熀鍥犱粛鐒跺彲浠ヨFAAH澶辨椿锛屼娇寰楀唴婧愭€уぇ楹荤礌AEA鍦ㄤ綋鍐呰仛闆嗐€?/p> 杩欎袱绉嶇獊鍙樼殑寮哄己鑱旀墜锛屼娇寰楀崱姊呴殕浣撳唴鐨勫唴婧愭€уぇ楹荤礌AEA鍚噺姣旀櫘閫氫汉瑕?strong>楂樺嚭涓ゅ€?/strong>锛?/p> 鎮ｈ€呰娑擦唴寰幆鑺辩敓閰拌兒锛圓EA锛夈€佹姒堥叞涔欓唶閰拌兒锛圥EA锛夈€佹补閰颁箼閱囪兒锛圤EA锛夌殑娴撳害鐩告瘮浜庡叾浠栧洓涓甯稿鐓ц楂樺嚭涓ゅ€嶅銆侫EA銆丳EA鍜孫EA鍧囦负FAAH鐨勫簳鐗┿€傦綔鍙傝€冭祫鏂橻1] 鍏跺疄锛屽叏涓栫晫涓嫢鏈夋棤鐥涜秴鑳藉姏鐨勪笉姝㈠崱姊呴殕涓€浜猴紝鍦ㄦ涔嬪墠灏辨湁鍏堝ぉ鎬х棝瑙変笉鏁忔劅鍚堝苟鏃犳睏鐥囷紙congenital insensitivity to pain with anhidrosis锛孋IPA锛?/strong>杩欎竴閬椾紶鎬х缁忛殰纰嶇棁锛屽叾涓村簥琛ㄥ緛鍖呮嫭鏃犳睏銆佺棝瑙夌己涔忕瓑銆傚畠鐨勫彂鐥呭師鍥犳槸鐢变簬鏌撹壊浣撲笂鐨勫熀鍥犵獊鍙橈紝浣垮緱渚濊禆瀹冪殑绁炵粡鐢熼暱闀垮洜瀛愶紙NGF锛夋棤娉曞悎鎴愶紝浠庤€屼娇绁炵粡鍏冮€愭笎鍑嬩骸锛屽鐥涜鏃犳硶娓呮櫚鎰熺煡銆?/p> 鎮ｆ湁CIPA鐥囩殑浜洪兘鏄洜涓虹缁忓鐤肩棝涓嶆晱鎰燂紝鑰屽儚鍗℃闅嗚繖鏍峰交搴曞け鍘荤柤鐥涙劅涓旀槸鐢卞熀鍥犵獊鍙樺師鍥犻€犳垚鐨勮繕鏄叏鐞冮渚嬨€?/p> 鍗℃闅嗚韩涓婅繖绉嶅鎬殑绐佸彉鏄€庝箞鏉ョ殑锛熺爺绌朵汉鍛樿瘯鍥句粠鍗℃闅嗙殑瀹舵棌閬椾紶涓壘绛旀銆?/p> 鍗℃闅嗗拰濂圭殑鑰佸叕銆佸効濂筹綔BBC 鍗℃闅嗕竴鐩村拰涓堝か鐢熸椿鍦ㄤ竴璧凤紝鍎垮コ鍙屽叏锛屽ス鐨勫鏃忓彶涓病鏈夊嚭鐜拌繃鏄庢樉鐨勭缁忕梾鍙樻垨鏃犵柤鐥涙劅鐨勬儏鍐碉紝濂圭殑姣嶄翰鍜屽コ鍎块兘鑳芥甯稿湴鎰熺煡鍒扮柤鐥涖€傜爺绌跺洟闃熻涓猴紝鍗℃闅嗗彲鑳芥槸浠庣埗浜查偅閲岄仐浼犲埌浜嗗熀鍥犵獊鍙?/strong>銆傚洜涓哄崱姊呴殕鐨勭埗浜茬敓鍓嶅緢灏戠敤姝㈢棝鑽紝鑰屽崱姊呴殕鐨勫効瀛愬鐤肩棝涔熶笉鏁忔劅锛岀粡甯歌鐑ギ鏂欐垨椋熺墿鐑机鍢村反锛屼絾绋嬪害杈冭交銆?/p> 鍦˙BC鍙戝竷鐨勪竴涓棰戜腑锛屽崱姊呴殕鍜屽ス鐨勪笀澶€侀夯閱夊尰鐢熶竴鍚屾寫鎴樹笘鐣屼笂鏈€杈ｇ殑杈ｆ涔嬩竴鐨勮嫃鏍煎叞绾㈠附妞掞紙Scotch bonnet锛夈€傚悆涓嬭荆妞掑悗锛屼袱涓敺浜哄緢蹇彉寰楁弧鑴搁€氱孩锛岀洿鍛肩棝鑻︼紝鑰屽浜庡崱姊呴殕鑰岃█锛岄偅鍙槸涓€闃碘€滀护浜烘剦鎮︾殑鐏肩儹鎰熲€?/strong>銆?/p> 鈥滆嫃鏍煎叞绾㈠附妞掓寫鎴樷€濓紝宸︿晶涓哄崱姊呴殕鐨勪笀澶獼im锛屽彸渚т负楹婚唹鍖荤敓Devjit Srivastava銆傦綔BBC 闄や簡浜虹被澶栵紝鑷劧鐣屽瓨鍦ㄧ潃涓€绉嶄笌浜虹被鍩哄洜鐨凞NA鏈夐珮杈?0%鍒?3%鐩稿悓鐨勭壒娈婅€侀紶鈥斺€?strong>闈炴床瑁搁脊榧狅紙Heterocephalus glaber锛夛紝瀹冧滑涔熸棤娉曟劅鍙楀埌鐥涜 瑁搁脊榧犵殑瀵垮懡鑳借揪鍒?0宀侊紝鏄叾瀹冮紶绫荤敓鐗╁鍛界殑10鍊嶃€傦綔鍙傝€冭祫鏂橻5] 鍙戣〃浜嶴cience鐨勪竴椤圭爺绌朵腑锛屽痉鍥介┈鍏嬫柉路寰峰皵甯冨悤鍏嬪垎瀛愬尰瀛︿腑蹇冿紙MDC锛夌殑Gary Lewin鏁欐巿鐮旂┒缁勶紝閫夊彇浜嗕笁绉嶅父瀵艰嚧浜虹被鍜屽叾浠栧摵涔冲姩鐗╃毊鑲や骇鐢熺伡鐑ф劅鐨勫寲瀛︾墿璐紝瑙傚療瑁搁脊榧犲杩欎簺鐗╄川鐨勫弽搴斻€?/p> 缁撴灉鏄剧ず锛?strong>瀹冧滑瀵规崗鍜屾埑閫犳垚鐨勬満姊扮柤鐥涘弽搴旀甯革紝浣嗗閰稿強杈ｆ绱犵瓑鍖栧鎬у埡婵€娌℃湁鐩稿簲鐨勭柤鐥涘弽搴?/strong>銆傝繘涓€姝ョ爺绌跺彂鐜帮紝鏄８榧归紶TrkA鍙椾綋鍩哄洜鍙戠敓浜嗙獊鍙?/strong>锛屾墠浣垮緱杩欑鍔ㄧ墿娌℃湁鐤肩棝鎰熻銆?/p> 锛堝浘婧愬弬鑰冭祫鏂橻5]锛?/p> 瑁搁脊榧犵敓娲荤殑娲炵┐涓父鏈夋€ф儏鍑剁寷銆佸垎娉岄珮鍒烘縺鎬ф瘨娑茬殑绾冲灏旇殏铓侊紙Myrmicaria natalensis锛夋椿鍔紝澶氫簭浜嗚繖绉嶉仐浼犲彉寮傦紝楂樺師榧归紶鎵嶈兘鈥滄棤瑙嗏€濇瘨铓傝殎甯︽潵鐨勭棝鑻︼紝鐩稿畨鏃犱簨鍦颁笌瀹冧滑鐢熸椿鍦ㄤ竴璧枫€傜畝鍗曠殑绁炵粡绯荤粺杩樿兘鍑忓皯鑳介噺鐨勯渶姹傦紝杩欏浜庨€傚簲钀ュ吇鍖箯鐨勬伓鍔ｇ敓瀛樼幆澧冨叿鏈夐噸瑕佷环鍊笺€傛墍浠ワ紝绉戝瀹朵滑璁や负瑁?/strong>榧归紶瀵圭棝瑙夋瀬寮虹殑鑰愬彈鎬ф槸涓€涓嚜鐒堕€夋嫨淇冭繘鐢熺墿婕斿寲鐨勫吀鍨嬭寖渚?/strong>銆?/p> 锛堝浘婧怭xhere锛?/p> 鍦ㄦ鐥涜嵂婊ョ敤鐨勪粖澶╋紝瀵瑰崱姊呴殕杩欐牱鐨勫鐗圭梾渚嬩互鍙婅８榧归紶鐨勬繁鍏ョ爺绌讹紝瀵瑰尰瀛︾晫鏈夌潃閲嶈鎰忎箟銆?strong>鏈潵鎴栬鍙互FAAH-OUT鐨勫熀纭€涓婂紑鍙戦拡瀵圭柤鐥涖€佷机鍙ｆ剤鍚堜互鍙婄劍铏戠棁鐨勬柊鍨嬬枟娉曪紝灏嗘暟浠ヤ嚎璁＄殑鐥呬汉浠庢湳鍚庣柤鐥涖€佺劍铏戠棁鍜屾參鎬х柤鐥涚殑娣辨笂涓嫰鏁戝嚭鏉?/strong>銆?/p> 绁稿叜绂忔墍鍊氾紝绂忓叜绁告墍浼忋€傝櫧鐒舵棤鐥涚殑瓒呰兘鍔涜祴浜堜簡鍗℃闅嗗父浜洪毦浠ユ兂璞＄殑鐢熸椿浣撻獙锛屼絾濂逛綋鍐呮垚鍊嶆按骞崇殑鍐呮簮鎬уぇ楹荤礌锛屼粛鐒跺鍏惰蹇嗛€犳垚浜嗘案涔呮€х殑浼ゅ鈥︹€?/p> 鎵€浠ユ湁鏃讹紝鐥涘苟涓嶆槸涓€浠跺潖浜嬨€?/p> 浣犳兂浣撻獙濂圭殑鏃犵棝浜虹敓鍚楋紵 灏侀潰鏉ユ簮锛歅xhere 鍙傝€冭祫鏂欙細 [1]Habib A M , 聽Okorokov A L , 聽Hill M N , et al. Microdeletion in a pseudogene identified in a patient with high anandamide concentrations and pain insensitivity[J]. BJA British Journal of Anaesthesia, 2019. [2]https://www.ucl.ac.uk/news/2019/mar/woman-novel-gene-mutation-lives-almost-pain-free [3]https://www.youtube.com/watch?v=qp0y78VLwcQ [4]Petherick, A. Naked mole-rats don't feel the burn. Nature (2008). |
