Cell锛氱柤鐥涗笉浠呮槸涓€绉嶄笉鎰夊揩鐨勪綋楠岋紝瀹冭繕鍦ㄧ淮鎶よ偁閬
更新时间:2022-10-23
|
鐤肩棝锛屾槸鎴戜滑姣忎釜浜洪兘鐔熺煡鐨勪竴绉嶉潪甯镐笉鎰夊揩鐨勪綋楠屻€傚畠鏄敱绉颁负浼ゅ鎰熷彈鍣?/strong>鐨勬劅瑙夌缁忓厓琚縺娲诲紩鍙戙€傞暱鏈熶互鏉ワ紝鐤肩棝琚涓烘槸杩涘寲杩囩▼涓殑涓€绉嶆娴嬪拰淇濇姢鏈哄埗锛氬畠鍙互妫€娴嬪埌姝ｅ湪闈复鐨勫嵄闄╂垨浼ゅ锛屽苟鍙戝嚭鈥滆鍛娾€濓紝浠ヨ皟鑺傛垜浠鐤肩棝鐨勬劅鐭ュ拰鍥為伩琛屼负銆?/p> 鐒惰€屾渶杩戯紝绉戝瀹朵滑鍦ㄥ皬榧犱腑鍙戠幇锛岀柤鐥涗笉浠呬粎鏄竴涓崟绾殑璀︾ず淇″彿锛岃繖绉嶄笉鎰夊揩鐨勪綋楠屽彲鑳戒篃鍦ㄩ粯榛樺湴淇濇姢鐫€鎴戜滑銆傛崲鍙ヨ瘽璇达紝涔熻鐤肩棝鏈韩灏辨槸涓€绉嶄繚鎶ゆ満鍒躲€?/p> 杩戞棩锛屽彂琛ㄥ湪銆奀ell銆?/strong>涓婄殑涓€椤规渶鏂扮爺绌朵腑锛屾潵鑷?strong>鍝堜經鍖诲闄㈤瀵肩殑鐮旂┒鍥㈤槦鎻ず浜嗙柤鐥涚缁忓厓涓庣壒娈婅偁閬撶粏鑳烇紙鏉姸缁嗚優锛変箣闂寸殑鐩存帴鐩镐簰浣滅敤锛岃繖鏄竴绉嶅鏉傜殑淇″彿绾ц仈锛岄€氳繃閲婃斁淇濇姢鎬ч粡娑叉潵淇濇姢鑲犻亾灞忛殰鐨勫畬鏁存€с€?/strong>涓€鑸潵璇达紝鐤肩棝鏄偁閬撴參鎬х値鐥囷紙濡傜粨鑲犵値锛夌殑甯歌鐥囩姸锛屼絾璇ョ爺绌惰〃鏄庯紝鎬ユ€х柤鐥涗篃鍦ㄥ彂鎸ョ潃鐩存帴鐨勪繚鎶や綔鐢ㄣ€?/p> 鑲犻亾灞忛殰鏄敱涓婄毊缁嗚優缁勬垚锛屼笂闈㈣绮樻恫灞傝鐩栵紝鍏跺熀鏈姛鑳芥槸闃叉绠¤厰鍐呭鐗╂棤鑺傚埗鍦拌繘鍏ヤ笅灞傜粍缁囥€?/p> 鏉姸缁嗚優鍥犲叾鏉姸鐨勫瑙傝€屽緱鍚嶏紝瀹冧滑鏄竴绉嶇壒娈婄殑涓婄毊缁嗚優锛岃兘浜х敓绮樻恫鍜岀浉鍏宠泲鐧戒互褰㈡垚绮樻恫灞傘€傛垜浠殑鑲犻亾鍜屾皵閬撳氨甯冩弧浜嗘澂鐘剁粏鑳炪€傜矘娑擦眰鍦ㄧ淮鎸佽偁閬撳钩琛＄殑鍚屾椂闃擦尽缁勭粐琚井鐢熺墿娓楅€忋€傜矘娑擦眰缂洪櫡澧炲姞浜嗗鐥呭師浣撶殑鏄撴劅鎬э紝骞朵笌鐐庣棁鎬ц偁鐥呯殑鍙戝睍鏈夊叧銆?/p> 鍦ㄤ竴绯诲垪瀹為獙涓紝鐮旂┒浜哄憳瑙傚療鍒帮紝缂轰箯鐤肩棝绁炵粡鍏冪殑灏忛紶浜х敓鐨勪繚鎶ゆ€х矘娑茶緝灏戯紝骞朵笖鑲犻亾寰敓鐗╃粍鎴愪篃鍙戠敓浜嗗彉鍖?/strong>锛屾湁鐩婅弻鍜屾湁瀹宠弻鎵撶牬浜嗕笉骞宠 锛屼粠鑰岄€犳垚浜嗚偁閬撶敓鎬佸け璋冦€?/p> 涓轰簡闃愭槑杩欑淇濇姢鎬т覆鎵版槸濡備綍鍙戠敓鐨勶紝鍦ㄨ繖椤规柊鐮旂┒涓紝璇ュ洟闃熷垎鏋愪簡鏉姸缁嗚優鍦ㄥ瓨鍦ㄥ拰涓嶅瓨鍦ㄧ柤鐥涚缁忓厓鎯呭喌涓嬬殑琛屼负銆?/p> 浠栦滑鍙戠幇锛屾澂鐘剁粏鑳炵殑琛ㄩ潰鍚湁涓€绉嶈绉颁负RAMP1鐨勫彈浣擄紝瀹冭兘纭繚缁嗚優瀵圭浉閭荤殑鐤肩棝绁炵粡鍏冨仛鍑哄弽搴旓紝杩欎簺绁炵粡鍏冧細琚ギ椋熷拰寰敓鐗╀俊鍙枫€佹満姊板帇鍔涖€佸寲瀛﹀埡婵€鎴栨俯搴︾殑鍓х儓鍙樺寲婵€娲伙紝浠庤€屼娇瀹冧滑瀵圭柤鐥涗俊鍙蜂骇鐢熷弽搴斻€?strong>RAMP1鍙椾綋涔熷瓨鍦ㄤ簬浜虹被鐨勬澂鐘剁粏鑳炰腑銆?/strong> 鐮旂┒浜哄憳杩樿瀵熷埌锛屽綋鐤肩棝绁炵粡鍏冨彈鍒板埡婵€鏃讹紝RAMP1浼氫笌鐥涜绁炵粡鏈ⅱ閲婃斁鐨勭缁忚偨闄嶉挋绱犲熀鍥犵浉鍏宠偨锛圕GRP锛夎繛鎺ャ€傝繘涓€姝ョ爺绌惰〃鏄庯紝鐗瑰畾鐨勮偁閬撳井鐢熺墿婵€娲讳簡CGRP鐨勯噴鏀撅紝浠ョ淮鎸佽偁閬撳唴绋虫€併€?/strong> 鍥犳锛?strong>杩欎簺绁炵粡涓嶄粎浼氳鎬ユ€х値鐥囪Е鍙戯紝涔熶細鍦ㄦ甯告儏鍐典笅琚Е鍙?/strong>銆傜爺绌朵汉鍛樺彂鐜帮紝鍙鍛ㄥ洿鏈夊父瑙佺殑鑲犻亾寰敓鐗╋紝浼间箮灏卞彲浠ュ埡婵€绁炵粡锛屼娇鏉姸缁嗚優閲婃斁绮樻恫銆?strong>杩欎釜鍙嶉鍥炶矾纭繚浜嗗井鐢熺墿鍚戠缁忓厓鍙戝嚭淇″彿锛岀缁忓厓璋冭妭绮樻恫锛岃€岀矘娑擦垯淇濇寔鑲犻亾寰敓鐗╃殑鍋ュ悍銆?/strong> 闄や簡寰敓鐗╀互澶栵紝鐮旂┒浜哄憳鍋囪楗鍥犵礌鍙兘涔熶細婵€娲讳机瀹虫劅鍙楀櫒骞惰瀵肩矘娑蹭骇鐢熴€?/p> 瀹為獙鏄剧ず锛屽綋鐮旂┒浜哄憳缁欏皬榧犲杺椋熻荆妞掔礌锛堣荆妞掔殑娲绘€ф垚鍒嗭級鏃讹紝鍔ㄧ墿鐨勭柤鐥涚缁忓厓杩呴€熻婵€娲伙紝浠庤€屽鑷存澂鐘剁粏鑳為噴鏀惧嚭澶ч噺鐨勪繚鎶ゆ€х矘娑层€傜浉姣斾箣涓嬶紝缂轰箯浼ゅ鎰熷彈鍣ㄦ垨涓婄毊Ramp1鐨勫皬榧犳洿瀹规槗鎮ｇ粨鑲犵値銆?/strong> 杩欎竴鍙戠幇鍙互瑙ｉ噴涓轰粈涔堣偁閬撹弻缇ゅけ璋冪殑浜烘洿瀹规槗鎮ｇ粨鑲犵値銆?/p> 鐤肩棝鏄値鐥囨€ц偁鐥呯殑涓昏鐥囩姸锛屼絾鎬ユ€х柤鐥涘強鍏朵即闅忕殑CGRP閲婃斁鍙兘浼氫繚鎶よ偁閬撳睆闅溿€傞€氳繃瀹為獙锛岀爺绌朵汉鍛樿瘉瀹烇紝浼ゅ鎰熷彈鍣ㄥ彲浠ラ槻姝㈢敱钁¤仛绯栫～閰搁挔璇卞鐨勭粨鑲犵値寮曡捣鐨勭梾鐞嗐€?/strong> 褰撶爺绌朵汉鍛樼粰浜堢己涔忎机瀹虫劅鍙楀櫒鐨勫皬榧燙GRP鍚庯紝灏忛紶鑲犻亾鐨勭矘娑擦垎娉岃繀閫熷鍔犮€傚嵆浣垮湪浼ゅ鎰熷彈鍣ㄧ己澶辩殑鎯呭喌涓嬶紝杩欑娌荤枟涔熻兘淇濇姢鍔ㄧ墿鍏嶅彈缁撹偁鐐庣殑渚靛銆傝繖涓€鍙戠幇琛ㄦ槑锛?strong>CGRP鏄鑷翠繚鎶ゆ€х矘娑擦垎娉屼俊鍙风骇鑱斿弽搴旂殑鍏抽敭鍒烘縺鍥犲瓙銆?/strong>
鎬讳箣锛岃繖浜涘彂鐜拌〃鏄庯紝浼ゅ鎰熷彈鍣ㄧ缁忓厓鍙婂叾閫氳繃CGRP-Ramp1杞村悜鏉姸缁嗚優鍙戝嚭淇″彿鍦ㄨ偁閬撳睆闅滀繚鎶や腑鍙戞尌鐫€鍏抽敭浣滅敤銆?/strong>鍥犳锛屼笌妫€娴嬫綔鍦ㄤ机瀹冲苟鍚戝ぇ鑴戝彂閫佷俊鍙风殑缁忓吀宸ヤ綔鐩告瘮锛岀柤鐥涘彲鑳戒互鏇寸洿鎺ョ殑鏂瑰紡鍦ㄤ繚鎶ょ潃鎴戜滑銆傝繖鎰忓懗鐫€绁炵粡绯荤粺鍦ㄨ偁閬撲腑鐨勪富瑕佷綔鐢ㄤ笉浠呬粎鏄粰鎴戜滑甯︽潵涓嶆剦蹇殑鎰熻锛屽畠涔熸槸鑲犻亾灞忛殰缁存姢鐨勫叧閿鑹诧紝浠ュ強鐐庣棁鏈熼棿鐨勪繚鎶ゆ満鍒躲€?/p> 璁烘枃閾炬帴锛?/strong> https://doi.org/10.1016/j.cell.2022.09.024 |
