鏈€鏂板彉寮傛牚 XBB.1.5锛屽鑷翠弗閲嶈吂娉伙紵鏇村鏄撲簩娆℃劅鏌擄紵
更新时间:2023-01-05
褰撳墠鎴戝浗涓昏娴佽鏂板啝鐥呮瘨鏍粛鐒惰繕鏄?BA.5.2 鍙?BF.7锛屼絾鏂板彉寮傛牚鍥藉娴佽銆佸叆澧冨浗鍐呯殑鎯呭喌锛屼竴鐩存槸鍏紬鎷呭咖鐨勭劍鐐逛箣涓€銆備笉鍒颁竴涓湀鏃堕棿锛岃骞挎硾璁ㄨ鐨勬柊姣掓牚灏卞凡缁忎粠銆屽湴鐙辩姮銆?BQ.1.1 鍙樻垚浜?XBB銆乆BB.1.5銆?/p> 銆孹BB 浼氬湪鎴戝浗寮曡捣鏂颁竴杞祦琛屽悧锛熴€嶇殑鎷呭咖涓€搴﹀啿涓婄儹鎼滅涓€锛屻€屾渶鏂板彉寮傛牚 XBB.1.5 涓撴敾鑳冭偁閬撳拰蹇冭剳琛€绠°€嶇殑璋h█杩呴€熷紩鍙戜簡鏂颁竴娉㈠洡鑽氮娼€?/p> 寮曡捣涓ラ噸鑵规郴锛屾劅鏌?XBB 鏇翠弗閲嶏紵 XBB 涓烘柊鍐犵梾姣?Omicron BA.2 鍒嗘敮绐佸彉杩涘寲鑰屾潵锛屾槸 BJ.1 鍜?BA.2.75 浜氱郴鐨勯噸缁勬祦琛屾牚銆?/p> SARS-CoV-2 Omicron BQ.1銆丅Q.1.1銆乆BB 鍜?XBB.1 浜氬彉浣?鍥炬簮锛氬弬鑰冩枃鐚?1 闅忕潃 XBB 绯诲垪瀛愪唬浜氬垎鏀粠鍗板害銆佹柊鍔犲潯绛夊浗瀹跺紑濮嬭繀閫熷湪鍏ㄧ悆娴佽寮€鏉ワ紝鍏跺瓙鍒嗘敮 XBB.1.5 鍥犲湪浼犳挱涓€愭笎鏄剧ず鍑轰簡杈冧负绐佸嚭鐨勪紭鍔胯€屽鍙楀叧娉ㄣ€?strong>鐒惰€屻€屾柊姣掓牚涓嶆敾鍑讳笂鍛煎惛閬撱€佹敼涓昏鏀诲嚮鑳冭偁閬撲簡銆嶇殑浼犺█鍗村苟闈炰簨瀹炪€?/strong> 鍛曞悙銆佽吂娉荤瓑鑳冭偁閬撳弽搴旓紝涓€鐩翠互鏉ュ湪鏂板啝鍚勬瘨鏍劅鏌撲腑閮戒笉缃曡銆傝绠$揣寮犵礌杞寲閰?2 锛圓CE2锛変綔涓烘柊鍐犵梾姣掔粨鍚堢粏鑳炵殑涓昏鍙椾綋锛岄櫎鍦ㄨ偤閮ㄨ〃杈惧锛屽湪鑲犻亾鐨勫惈閲忎篃杈冮珮銆傛柊鍐犵梾姣掑悇涓彉寮傛牚锛屽寘鎷?XBB 绯诲垪鍙樺紓鏍紝閮戒細鎰熸煋鑲犻亾榛忚啘缁嗚優銆傚洜涓轰釜浣撳樊寮傜殑瀛樺湪锛屾槸鍚﹀嚭鐜拌偁閬撲复搴婄棁鐘跺垯鍥犱汉鑰屽紓銆?strong>鍥犳锛孹BB.1.5 杩欎竴杩涘寲鍒嗘敮鍚屾牱涔熸湁鍙兘瀵艰嚧鑳冭偁閬撶棁鐘讹紝浣嗙洰鍓嶅苟娌℃湁璇佹嵁鎻愮ず瀹冩瘮鍏朵粬姣掓牚鏇村鏄撳鑷翠弗閲嶇殑鑵规郴銆?/strong> 鍚屾牱锛屾劅鏌?XBB 浼氭洿涓ラ噸锛屼篃骞舵棤璇佹嵁鏀寔銆侽micron 娴佽鏈熼棿锛屼富瑕佹瘨鏍湪涓嶆柇鏇存浛锛?strong>浣嗕笉璁烘槸鎰熸煋鍚庤交鐥囩殑鐥囩姸缇よ〃鐜帮紝杩樻槸閲嶇棁鐜囥€佺梾姝荤巼锛岄兘鏈鏄庢樉鍙樺寲銆?/strong>浠ユ柊鍔犲潯涓轰緥锛屽幓骞?10锝?1 鏈堢殑 XBB 鐤儏楂樺嘲锛屽甫鏉ョ殑姝讳骸浜烘暟娉㈠嘲骞朵笉绐佸嚭銆傛柊鍔犲潯鏀垮簻 10 鏈?14 鏃ユ浘鍙戝竷淇℃伅锛屾病鏈夎瘉鎹〃鏄?XBB 姣斾互鍓嶇殑绐佸彉鏍洿鍏锋湁鑷寸梾鎬э紝鐢氳嚦涓?Omicron BA.5 鐩告瘮锛孹BB 鐨勪綇闄㈤闄╅檷浣庝簡 30%銆?/p> 鍥炬簮锛歸orldometer Nature 鎶ラ亾瀵规鎸囧嚭锛?strong>鍦?XBB 娴佽鏈熼棿锛屾柊鍔犲潯鐨勬柊鍐犱綇闄㈠拰姝讳骸浜烘暟鐣ユ湁涓婂崌锛屼絾杩欎簺褰卞搷鐨勪弗閲嶇▼搴﹁灏忎簬浠ュ線鐨勭獊鍙樻牚銆?/strong> 10 鏈?27 鏃ワ紝WHO 瀵?BQ.1 鍜?XBB 涓ょ姣掓牚鍏紑鍙戣〃澹版槑锛岃〃绀哄綋涓嬫病鏈夋暟鎹敮鎸?XBB 瀵艰嚧鐨勭柧鐥呬弗閲嶇▼搴︿笌 Omicron BA.5 绯诲瓨鍦ㄦ樉钁楀樊寮傘€傚嵃搴︾敱 54 涓疄楠屽缁勬垚鐨勬柊鍐?SARS-CoV-2 鍩哄洜缁勫鑱旂洘锛圛NSACOG锛夊湪瀵规柊鍐犵獊鍙樻牚鐨勬娴嬩腑锛屽悓鏍锋病鏈夊彂鐜?XBB 涓庣柧鐥呬弗閲嶇▼搴﹀鍔犱箣闂寸殑鐩稿叧鎬с€?/p> 瀵逛簬鏈€鏂扮殑 XBB.1.5 鍙樺紓鏍紝缇庣柧鎺т腑蹇冩柊鍐犲拰鍏朵粬鍛煎惛閬撶梾姣掗儴闂ㄤ富浠?Barbara路Mahon 涔熻〃绀猴紝娌℃湁杩硅薄琛ㄦ槑 XBB.1.5 浼氭瘮鍏朵粬 Omicron 鍙樺紓姣掓牚瀵艰嚧鏇翠弗閲嶇殑鐤剧梾锛?/strong>鐩墠铏界劧鍏ㄧ編鐨勬柊鍐犱綇闄㈢巼鏈夋墍涓婂崌锛屼絾 XBB.1.5 鐩涜鐨勭編鍥戒笢鍖楀湴鍖轰綇闄㈢巼骞舵湭鍑虹幇涓嶆垚姣斾緥鐨勬縺澧炪€?/p> 鍏嶇柅閫冮€歌兘鍔涘己锛屼簩娆℃劅鏌撻毦閬垮厤锛?/strong> 鍏嶇柅閫冮€歌兘鍔涙槸鏄惁瀹规槗鍙戠敓浜屾鎰熸煋鐨勫熀纭€銆傚寳浜ぇ瀛﹁阿鏅撲寒/鏇逛簯榫欏洟闃熻繎鏃ュ彂甯冪殑鐮旂┒鏄剧ず锛孹BB 鐩稿浜?BQ.1 鐨勪紭鍔垮彲鑳藉湪浜庡埡绐佽泲鐧藉彈浣撶粨鍚堝煙锛圧BD锛変箣澶栫殑绐佸彉銆?strong>涓?BQ.1 鐩告瘮锛孹BB 鍦ㄥ埡绐佽泲鐧?N 绔粨鏋勫煙锛圢TD锛変笂涔熸湁杈冨鐨勭獊鍙橈紝鍥犳鍏惰兘澶熸洿瀹规槗閫冮€搁拡瀵?NTD 鐨勪腑鍜屾姉浣?/strong> [2]銆?/strong> 12 鏈?13 鏃ワ紝Cell 鍦ㄧ嚎鍒婂彂浜嗕綍澶т竴鍥㈤槦鍏充簬 BQ 绯诲拰 XBB 绯荤殑鐮旂┒鍚屾牱璇佸疄浜?XBB 鐨勮秴寮哄厤鐤€冮€歌兘鍔涖€傜爺绌堕噰鐢ㄤ簡鐤嫍鎺ョ鑰呭拰鏃㈠線鎰熸煋鑰呯殑琛€娓咃紝鍏朵腑鍖呮嫭鎺ョ浜?BA.5 浜屼环 mRNA 鐤嫍鐨勪釜浣擄紝缁撴灉鏄剧ず锛岄拡瀵?BQ 绯荤獊鍙樻牚鐨勪腑鍜屾椿鎬у垎鍒檷浣?13 鑷?81 鍊嶄笉绛夛紝閽堝 XBB 绯荤獊鍙樻牚鐨勪笅闄嶅垯鏇翠负鏄庢樉锛屼负 66 鑷?155 鍊嶄笉绛?[1]銆?/p> 鍥炬簮锛氬弬鑰冩枃鐚?1 浠ヤ笂 XBB 绯诲垪鍙樺紓鏍殑鐩稿叧鐮旂┒锛岄兘鏈秹鍙?XBB.1.5 杩欎竴鏈€鏂板彉寮傛牚銆傜洰鍓嶇編鍥?CDC 鐨勭洃娴嬫暟鎹樉绀猴紝杩戝嚑鍛?XBB 绯诲垪鍙樺紓鏍崰姣斿鍔犳湡闂达紝鏂板啝鎰熸煋鑰呮姤鍛婃暟銆佷綇闄㈢梾渚嬫暟銆佹浜$梾渚嬫暟骞舵湭鍑虹幇鏄捐憲澧為珮銆?strong>XBB.1.5 鍦?2022 骞寸殑鏈€鍚庝竴鍛ㄥ崰姣旀樉钁椾笂鍗囷紝浣嗗叾寮曡捣鐨勫啀鎰熸煋姣旂巼锛屼緷鐒堕渶瑕佽繘涓€姝ヨ瀵熴€?/strong> 鐒惰€岋紝姣掓牚鐨勫厤鐤€冮€歌兘鍔涘嵈涓嶈兘鐩存帴涓庝簩娆℃劅鏌撳嚑鐜囩敾绛夊彿銆傝憽钀勭墮鐨勪竴椤圭爺绌舵浘鏄剧ず锛孊A.5 铏界劧瀵?BA.1 鎴?BA.2 鍏锋湁鍏嶇柅閫冮€革紝浣嗗紩璧风殑鎰熸煋楂樺嘲鏄庢樉浣庝簬 BA.1 鏃舵湡銆傝繘涓€姝ョ殑鍒嗘瀽鏄剧ず锛屽湪闂撮殧绾?90 澶╃殑涓ゆ Omicron 鐤儏涓紝BA.1 鎴?BA.2 杩囧線鎰熸煋瀵?BA.5 鐨勯槻鎰熸煋鏈夋晥鎬ч珮杈?75.3% [3]銆?/p> 鍥炬簮锛氬弬鑰冩枃鐚?3 涓嶅悓 Omicron 浜氭牚闂寸‘瀹炲湪鍏嶇柅閫冮€镐笂瀛樺湪宸紓锛?strong>浣嗗氨涓綋鑰岃█锛岀煭鏈熷唴鍐嶆劅鏌撶殑椋庨櫓浠嶇劧杈冧綆銆?/strong> 鏈湡鐥呬緥妫€鍑猴紝XBB 灏嗗紩鍙戞柊鎰熸煋楂樺嘲锛?/strong> XBB.1.5 浠?RBD 涓婄殑 F486P 绐佸彉鍙栦唬 XBB 鐨?F486S锛岃繖涓€姘ㄥ熀閰哥疆鎹娇 XBB 鍏锋湁浜嗗厤鐤€冮€哥殑鐗规€э紝鍚屾椂浣跨梾姣掍笌 ACE2 缁撳悎鑳藉姏澧炲己锛屾彁楂樹簡浼犳挱鑳藉姏銆傚洜涓?XBB 绯诲垪绐佸彉鏍暣浣撲笂鍏锋湁杈冨ぇ鐨勯噸缁勫彉鍖栵紝WHO 鏇句簬 2022 骞?10 鏈堣璁烘槸鍚﹂渶瑕佷互涓€涓壒娈婂笇鑵婂瓧姣嶅懡鍚嶃€俉HO 鍦ㄤ細璁粨璁轰腑鏄庣‘鎸囧嚭锛?strong>XBB 鍏锋湁寰堥珮鐨勫啀鎰熸煋鍜岀柅鑻楀厤鐤獊鐮存綔鍔涳紝浣嗙洰鍓嶄负姝㈣繕娌℃湁娴佽鐥呭璇佹嵁琛ㄦ槑 XBB 涓庡叾浠?Omicron 浜氱郴鐩告瘮鍏锋湁鏇村ぇ鐨勯闄╋紝鎵€浠ヤ粛灏?XBB 瑙嗕负 Omicron 鐨勪竴閮ㄥ垎銆?/strong> XBB 绯诲垪鍙樺紓鏍棭鍦?2022 骞?10 鏈堝凡鍦ㄥ嵃搴﹀拰鏂板姞鍧$瓑浜氭床鍥藉寮曞彂涓€杞劅鏌撱€傚叏鐞冩祦鎰熷叡浜暟鎹簱锛圙ISAID锛夌殑鏁版嵁鏄剧ず锛屾埅鑷?2022 骞?12 鏈?31 鏃ワ紝鍏ㄧ悆鑷冲皯 74 涓浗瀹跺拰鍦板尯宸叉娴嬪嚭 XBB.1.5銆傜編鍥界柧鐥呮帶鍒跺拰棰勯槻涓績鏈€鏂版暟鎹樉绀猴紝鎴嚦 2022 骞?12 鏈?31 鏃ワ紝缇庡浗 40% 鐨勬柊鍐犵‘璇婄梾渚嬫劅鏌撲簡 XBB.1.5锛岃€屾鍓嶄竴鍛ㄧ殑鏁版嵁涓?20%锛堣緝涓虹洓琛岀殑涓滃寳鍦板尯 XBB.1.5 鎰熸煋宸擦崰纭瘖鐥呬緥鐨?3/4锛夈€?/p> 鍥炬簮锛氱編鍥?CDC 瀹樼綉 鎴戝浗鐩墠鏈湡娴佽鐨勭粷瀵逛紭鍔挎瘨鏍紝浠嶇劧鏄?BA.5.2 鍜?BF.7銆傛牴鎹腑鐤炬帶 1 鏈?4 鏃ョ殑姹囨€讳俊鎭紝2022 骞?10锝?2鏈堬紝鎴戝浗閫氳繃鍩哄洜缁勬祴搴忓凡鍙戠幇杈撳叆 XBB 鐥呬緥 199 渚嬶紝鍖呮嫭 9 涓簹鍒嗘敮锛屽叾涓?4 渚嬩负 XBB.1.5 杈撳叆鐥呬緥銆傝€屽浜庢湰鍦熺梾渚嬶紝10锝?2 鏈堝叡鎶ュ憡鍙戠幇鏈湡 XBB 鐥呬緥 16 渚嬶紝鍏ㄩ儴涓?XBB.1 杩涘寲鍒嗘敮锛屾殏鏈洃娴嬪埌 XBB.1.5 鏈湡鐥呬緥銆?/strong> 涓柧鎺у悓鏃剁爺鍒わ紝浜轰綋鍦ㄦ劅鏌撳悗浜х敓鐨勪腑鍜屾姉浣擄紝鍦ㄧ煭鏈熷唴锛? 涓湀锛変細缁存寔鐩稿杈冮珮姘村钩锛岄鏈熷鍏朵粬聽Omicron聽鍙樺紓鏍垎鏀湁娼滃湪鐨勪氦鍙変繚鎶や綔鐢ㄣ€傛垜鍥界煭鏈?锛? 涓湀锛夊唴锛岀敱 XBB 绯诲垪鍙樺紓鏍紝鍖呮嫭 XBB.1.5 寮曞彂澶ц妯℃祦琛岀殑鍙兘鎬ф瀬浣庛€?/p> 鑷磋阿锛氭湰鏂囩粡聽涓浗绉戝闄㈠井鐢熺墿瀛﹀崥澹€佺煡鍚嶇瀛﹀崥涓?@浜屾墜鐨勭瀛﹀ 涓撲笟瀹℃牳 绛栧垝锛氫簯涔熉爘 鐩戝埗锛歡youza 棰樺浘鏉ユ簮锛氬浘铏垱鎰?/p> 鍙傝€冩枃鐚細 [1] Wang Q, Iketani S, Li Z, et al. Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants[J]. Cell, 2022. [2] Cao Y, Jian F, Wang J, et al.聽Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution. Nature. 2022 Dec 19. [3] Malato J, Ribeiro R M, Leite P P, et al. Risk of BA. 5 infection among persons exposed to previous SARS-CoV-2 variants[J]. New England Journal of Medicine, 2022, 387(10): 953-954. |