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鍥? 涓栫晫鍗敓缁勭粐璺熻釜鏂板啝鍙樹綋锛堝浘婧愶細[1]锛?/i>

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鍥? 2020骞?鏈?2023骞?鏈堬紝鏂板姞鍧℃柊鍐犲彉浣撶梾渚嬫暟鎹紙鍥炬簮锛氭柊鍔犲潯鍗敓閮級

XBB绯诲垪锛氳縿浠婁负姝紝鎶垫姉鍔涙渶寮虹殑鏂板啝鐥呮瘨鍙樹綋

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鍥? XBB绯荤粺杩涘寲鍒嗘瀽锛堝浘婧愶細[2]锛?/i>

01

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2021骞村簳鍑虹幇鐨凮micron浜氬彉浣撶粡鍘嗕簡瓒嬪悓杩涘寲锛屽ぇ閮ㄥ垎鍙樺寲鍙戠敓鍦?strong>鍒虹獊铔嬬櫧涓娿€?strong>杩欑铔嬬櫧璐ㄤ綅浜庡啝鐘剁梾姣掍箣澶栵紝浣垮叾鑳藉绌块€忓涓荤粏鑳炲苟寮曡捣鎰熸煋銆傚埡绐佽泲鐧界殑涓€浜涘彇浠e鍔犱簡鍏朵笌ACE2鎴栬绠$揣寮犵礌杞寲閰?鍙椾綋缁撳悎鐨勮兘鍔涳紝甯姪瀹冮€冮伩鍏嶇柅鎺ョ鎴栦互鍓嶆劅鏌撲骇鐢熺殑鎶椾綋銆備紶鎾晥鐜囨洿楂樼殑Omicron浜氬彉浣撴槸浠庝竴涓氨绯讳腑鐨勫崟涓€绐佸彉涓幏寰楄繖浜涘彇浠o紝渚嬪锛屾柊鍑虹幇鐨勪簹鍙樹綋BQ.1.1鏄疊A.5鐨勫悗浠o紝浣嗘槸XBB鍗翠笌浼椾笉鍚屻€?strong>2022骞村瀛o紝XBB鍦ㄥ嵃搴﹂檮杩戦噸缁勮€屾垚锛岃繖绉嶉噸缁勫湪浠ュ線鐨勫啝鐘剁梾姣掑彉寮備綋涓槸鐪嬩笉鍒扮殑[2]銆?/p>

02

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03

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鍥? 鏂板啝鍙樹綋BQ鍜孹BB瀵规姉浣撶殑瓒呭己閫冮伩锛堝浘婧愶細[4]锛?/i>

04

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宸叉湁鍓嶈溅涔嬮壌锛岀悊鎬ч潰瀵硅繘鍏ヤ腑鍥界殑XBB

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鍥? 缇庡浗鏂板啝鐥呮瘨鎰熸煋姣掓牚鏋勬垚姣旓紙鍥炬簮锛歔6]锛?/i>

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棣欐腐澶у鐥呮瘨瀛﹀閲戜笢鐕曡〃绀猴細鈥?strong>XBB.1.5骞舵病鏈夊鑷寸編鍥芥劅鏌撱€佷綇闄㈡垨姝讳骸浜烘暟鏄捐憲澧炲姞銆俋BB.1.5甯︽潵鐨勬縺澧烇紙濡傛灉鏈夌殑璇濓級杩滃皬浜?022骞村垵鍙戠敓鐨勬縺澧炪€備笉蹇呰繃澶氭媴蹇冨叾姣掑姏鎴栦簩娆℃劅鏌撶殑鍚庢灉銆?/strong>鈥?/p>

琚玁ature璇勪负鈥?022骞村府鍔╁閫犵瀛?0澶т汉鐗┾€濅箣涓€鐨勫寳澶ф浌浜戦緳鏁欐巿琛ㄧず:鈥?strong>涓浗澶у鏁颁汉宸茬粡鎺ョ浜嗙鍏堟牚鐤嫍锛屽叾璇卞鐨勪綋娑擦厤鐤XBB杩欑omicron绐佸彉鏍嚑涔庢棤鏁堛€傛劅鏌揃A.5.2鎴朆F.7搴峰鍚庯紝浜轰綋浜х敓鐨勬姉浣撳XBB绛夋渶鏂板彉寮傛瘨鏍殑涓拰鑳藉姏杈冧綆銆傚彲浠ラ瑙侊紝鍦ㄤ腑鍥紹A.5.2鍜孊F.7鎰熸煋楂樺嘲娑堥€€鍚庯紝鍙兘浼氬嚭鐜扮敱BQ.1.1銆乆BB鎴栧叾浠栧厤鐤€冮€歌兘鍔涙洿寮虹殑姣掓牚椹卞姩鐨勬劅鏌撻珮宄般€?/strong>鈥?/p>

閽堝XBB鏄惁浼氬鑷磋偁閬撶柧鐥咃紝鍖椾含浣戝畨鍖婚櫌鍛煎惛涓庢劅鏌撶鏉庝緱鏇惧尰鐢熻〃绀猴細鈥?strong>浣滀负鏂板啝鐥呮瘨缁撳悎缁嗚優鐨勪富瑕佸彈浣擄紝ACE2闄や簡鍦ㄨ偤閮ㄨ〃杈惧锛屽湪鑲犻亾鐨勫惈閲忎篃杈冮珮銆傛柊鍐犵梾姣掑悇涓彉寮傛牚閮戒細鎰熸煋鑲犻亾绮樿啘缁嗚優锛屼絾鏄敱浜庝釜浣撳樊寮備細鍐冲畾鏄惁浼氬嚭鐜拌偁閬撲复搴婄棁鐘躲€傚浜庢渶杩戝彈鍒板叧娉ㄧ殑XBB鍙婂叾杩涘寲鍒嗘敮锛屽苟娌℃湁璇佹嵁琛ㄦ槑姣斿叾浠栨瘨鏍洿瀹规槗瀵艰嚧涓ラ噸鑵规郴鎴栧叾浠栬儍鑲犻亾涓村簥琛ㄧ幇銆?/strong>鈥?/p>

鎾版枃|鏂囩珵鎷?/p>

鎺掔増|涔旂淮閽?/p>

End

鍙傝€冭祫鏂欙細

[1]Ngiam, Jinghao Nicholas MBBS; Al-Mubaarak, Abdurrahmaan BSc; Maurer-Stroh, Sebastian PhD, et al. Does the COVID-19 XBB Omicron subvariant signal the beginning of the end of the pandemic? Singapore Medical Journal锛孌ecember 01, 2022. DOI: 10.4103/singaporemedj.SMJ-2022-180.

[2]Tomokazu Tamura , Jumpei Ito , Keiya Uriu , et al. Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants. bioRxiv 2022.12.27.521986; doi: https://doi.org/10.1101/2022.12.27.521986

[3]Uraki R, Ito M, Furusawa Y, et al. Humoral immune evasion of the omicron subvariants BQ.1.1 and XBB. Lancet Infect Dis. 2023 Jan;23(1):30-32. doi: 10.1016/S1473-3099(22)00816-7. Epub 2022 Dec 7. PMID: 36495917; PMCID: PMC9729000.

[4]Wang Q, Iketani S, Li Z, et al. Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants. Cell. 2022 Dec 14:S0092-8674(22)01531-8. doi: 10.1016/j.cell.2022.12.018. Epub ahead of print. PMID: 36580913; PMCID: PMC9747694.

[5]Imai M, Ito M, Kiso M, et al. Efficacy of Antiviral Agents against Omicron Subvariants BQ.1.1 and XBB. N Engl J Med. 2022 Dec 7:NEJMc2214302. doi: 10.1056/NEJMc2214302. Epub ahead of print. PMID: 36476720; PMCID: PMC9749618.

[6]https://covid.cdc.gov/covid-data-tracker/#variant-proportions

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