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doi.org/10.1016/j.jaci.2022.09.037

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doi.org/10.1016/j.jaci.2022.09.037

TLR3鍒烘縺鐨凟V琛ㄧ幇鍑烘湁鏁堢殑鎶楀懠鍚搁亾鐥呮瘨娲绘€?/strong>

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doi.org/10.1016/j.jaci.2022.09.037

TLR3鍒烘縺涓婅皟EV涓殑miR-17澧炲己鎶楃梾姣掓椿鎬?/strong>

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閲囩敤qPCR璇佸疄涓庢湭鍙楀埡婵€瀵圭収缁嗚優鐩告瘮锛孴LR3鍒烘縺鏄剧潃澧炲姞浜咵V涓璵iR-17鐨勮〃杈撅紱鍦ㄦ湭鍙楀埡婵€瀵圭収缁嗚優涓紝miR-17杩囪〃杈炬垨娌夐粯鍙戠幇miR-17鎶戝埗浜嗙梾姣扲NA澶嶅埗锛屾樉钁楅檷浣庝簡瀹夸富缁嗚優涓瑿oV_OC43銆丷V-1B鍜孯V-16鐥呮瘨mRNA姘村钩锛岃瘉瀹炰簡miR-17瀵瑰懠鍚搁亾鐥呮瘨鐨勫己澶ф姉鐥呮瘨娲绘€с€傚湪TLR3鍒烘縺鐨勭粏鑳炰腑锛屽悓鏍疯繘琛宮iR-17杩囪〃杈炬垨娌夐粯锛屽彂鐜颁笌鏈彈鍒烘縺瀵圭収缁嗚優鐩告瘮锛孴LR3鍒烘縺璇卞鐨凟V涓璵iR-17鎶楃梾姣掓椿鎬ф洿寮猴紝璇佸疄TLR3鍒烘縺涓婅皟EV涓殑miR-17澧炲己鎶楃梾姣掓椿鎬с€?/p>

doi.org/10.1016/j.jaci.2022.09.037

TLR3鍒烘縺鐨凟V琛ㄩ潰鍙椾綋-鐥呮瘨缁撳悎

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doi.org/10.1016/j.jaci.2022.09.037

鍐锋毚闇蹭細鎹熷TLR3渚濊禆鎬V鍒嗘硨

鍜宮iR-17涓板害

浠庤€屾秷闄ゆ姉鐥呮瘨娲绘€?/strong>

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鎺ヤ笅鏉ョ爺绌跺喎鏆撮湶瀵筎LR3鍒烘縺鐨凟V浠嬪鐨勬姉鐥呮瘨娲绘€х殑褰卞搷锛屽彂鐜板喎鏆撮湶涓婽LR3渚濊禆鎬V鎶楃梾姣掓椿鎬ч檷浣庯紝miR-17鐨勪赴搴﹂檷浣庯紝琛ㄦ槑鍐锋毚闇擦彲鑳介€氳繃杩欑鏈哄埗鏉ユ秷闄ゆ姉鐥呮瘨娲绘€с€?/p>

doi.org/10.1016/j.jaci.2022.09.037

鍐锋毚闇查檷浣嶵LR3渚濊禆鎬V琛ㄩ潰鍙椾綋铔嬬櫧琛ㄨ揪锛屾崯瀹崇敱琛ㄩ潰鍙椾綋-鐥呮瘨鐩镐簰浣滅敤浠嬪鐨勬姉鐥呮瘨娲绘€?/strong>

鍦?7鈩冩椂锛屼笌鏈埡婵€瀵圭収缁嗚優鐩告瘮锛孴LR3鍒烘縺EV涓璍DLR銆両CAM-1琛ㄨ揪鏄捐憲澧炲姞锛岃€屽綋娓╁害闄嶅埌32鈩冩椂锛孴LR3鍒烘縺EV涓璍DLR銆両CAM-1鏄捐憲鍙楁崯锛岃〃鏄嶵LR3鍒烘縺EV涓〃闈㈠彈浣撹泲鐧絃DLR鍜孖CAM-1琛ㄨ揪澧炲姞鍙楃幆澧冩俯搴﹀奖鍝嶃€傝繘涓€姝ョ爺绌跺彂鐜板喎鏆撮湶浼氭樉钁楁崯瀹崇敱琛ㄩ潰鍙椾綋-鐥呮瘨鐩镐簰浣滅敤浠嬪鐨勬姉鐥呮瘨娲绘€э紝浣嗘槸瀵逛簬TLR3鍒烘縺鐨凟V鎶楃梾姣掓椿鎬ф病鏈夋樉钁楀奖鍝嶃€?/p>

doi.org/10.1016/j.jaci.2022.09.037

灏忕粨

涓婂懠鍚搁亾鎰熸煋瀛樺湪瀛h妭鎬у彉鍖栵紝灏ゅ叾鍦ㄥ啲瀛o紝鎰熸煋鐜囧鍔狅紝杩欐槸鍥犱负鍐锋毚闇蹭細鎹熷鐢遍蓟涓婄毊EV浠嬪鐨勬姉鐥呮瘨鍏嶇柅闃擦尽鍔熻兘锛屼笖杩欏彲鑳芥槸閫氳繃涓嬭皟TLR3渚濊禆鎬V鍒嗘硨鍜宮iR-17涓板害锛岄檷浣嶵LR3渚濊禆鎬V琛ㄩ潰鍙椾綋铔嬬櫧琛ㄨ揪绛夋潵瀹炵幇鐨勩€?/p>

鎯充竴鎯筹紝鏂板啝鐨勫埌鏉ヤ娇寰楁垜浠涓嶅紑鍙g僵锛岃€屽彛缃╃殑瀛樺湪鍙互缁欎簣榧昏厰涓€瀹氱殑娓╂殩锛岄棿鎺ヤ繚鎶や簡榧诲唴鍏嶇柅闃擦尽鏈哄埗锛岄檷浣庝簡鍛煎惛閬撶梾姣掔殑鎰熸煋鍑犵巼锛屼篃涓嶅け涓哄張涓€涓埓鍙g僵鐨勭悊鐢便€?/p>

鍙傝€冩枃鐚細

[1] Di Huang, Maie S. Taha, Angela L. Nocera, Alan D. Workman, Mansoor M. Amiji, Benjamin S. Bleier,Cold exposure impairs extracellular vesicle swarm鈥搈ediated nasal antiviral immunity,

Journal of Allergy and Clinical Immunology,2022.聽doi.org/10.1016/j.jaci.2022.09.03

鏉ユ簮 |聽鐢熺墿璋?/p>

鎾扮 |聽M

缂栬緫 |聽cici

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